Preimplantation Genetic Diagnosis (PGD) India
Preimplantation genetic diagnosis (PGD) is being used increasingly at the Fertility Institutes to dramatically improve the chance of a successful IVF pregnancy in couples where prior IVF failures have remained unexplained. It has been estimated that over half of all IVF failures are not able to be explained by an apparent problem with embryo "quality". For many couples however, this statistic is quite misleading. Most IVF centers look very closely at the appearance of embryos under the microscope as they attempt to determine a "good" or "high quality" embryo from those of lesser quality...
IVF Success Following PGD
Single cycle IVF success rates (the chance of becoming pregnant)in our program can be raised significantly* when 2 or 3 embryos known to be chromosomally normal are transferred. The chance of healthy pregnancy may double when known genetically normal embryos are utilized. Implantation rates (the chance of each single embryo becoming a gestation) can also be raised greatly with PGD. To determine whether these embryos are chromosomally normal, a PGD analysis is carried out by our scientists prior to their selection for transfer to the mother. In an genetically normal embryo, there should be 2 (and only 2) chromosomes of each of 22 chromosome types in addition to one set of XX female or one set of the XY male chromosomes....
The Successful Use of PGD for Recurrent IVF Failure
Most couples presenting to us for consideration of PGD have one of the following conditions : -
- Prior unexplained IVF failure
- Recurrent miscarriages
- Maternal age over 38
- Conception of a chromosomally abnormal child or fetus
- Polycystic ovary syndrome
- History of ovarian hyperstimulation syndrome
- Heritable medical condition in either the patient or in a prior child (such as hemophilia)
And many more...
The Accuracy Of PGD In "Genetic" IVF Failure
The accuracy of PGD in determining genetic abnormalities exceeds 98%. Once we have the genetic information about each embryo available, we are able to sit down with each couple prior to the embryo transfer, discuss the genetic health of each embryo, explain how the genetic information has improved the chances for pregnancy success compared to their prior unsuccessful attempts at IVF elsewhere, and make a determination about the return of the now "known to be normal" embryos to the mother to be....
The Success Of PGD In Improving Recurrent IVF Failure
Using PGD to select the best embryos is clearly superior to traditional methods of selection. Miscarriage rates following PGD are far less than with standard IVF. Currently more than half of couples with two or more normal embryos and maternal age under 41 will take home a baby on a first IVF-PGD attempt in our program. And these are in couples who have failed multiple prior IVF attempts elsewhere!...
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